Ccl4 3d Model. There are many ways to induce nafld nash for preclinical rodent modeling methods include dietary manipulation employing high fat high cholesterol high fructose methionine choline deficient diets or combinations of the above chemotoxic agent induction and acute liver injury models. Carbon tetrachloride was first synthesized as a by product in the synthesis of chloroform.
Ccl4 treatment in mice causes significant fibrosis within a relatively short treatment period and it is still occasionally utilised for testing drugs that target the fibrotic aspect of nash. We exposed mice to ccl4 to assess whether egf and cd133 hscs are up regulated in chronically injured liver. A ccl4 lewis structure is a diagram that represents the electron configuration of covalently bonded compounds lewis structures are meant to provide a visualization of the atomic structure and the distribution of electrons in a given chemical compound.
Ccl4 treatment in mice causes significant fibrosis within a relatively short treatment period and it is still occasionally utilised for testing drugs that target the fibrotic aspect of nash.
A ccl4 lewis structure is a diagram that represents the electron configuration of covalently bonded compounds lewis structures are meant to provide a visualization of the atomic structure and the distribution of electrons in a given chemical compound. The compound has a chemical formula of ccl4 and is now banned from use as it has some toxic properties that can harm the central nervous system of humans. The carbon tetrachloride ccl4 induced mouse model has been historically relied upon to study liver injury and regeneration. Ccl4 in olive oil was administered to strain a j mice three times per week by oral gavage.
